Like all DMARDs, sulfasalazine takes time to work. Sulfasalazine may cause the skin or the urine to change color. Clin Neuropharmacol 31 (2008): 368-71, 9. Also nausea for the initial 4 weeks. Kawada A, Kobayashi T, Noguchi H, Hiruma M, Ishibashi A, Marshall J "Fixed drug eruption induced by sulfasalazine." Sulfasalazine may make you … "Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis." Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, increased sensitivity of the skin to sunlight, bluish color of the fingernails, lips, skin, palms, or nail beds, blistering, peeling, or loosening of the skin, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, redness, blistering, peeling, or loosening of the skin, sores, ulcers, or white spots in the mouth or on the lips, Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. Keisu M, Ekman E "Sulfasalazine associated agranulocytosis in sweden 1972-1989: clinical features, and estimation of its incidence." Abnormal Urine Color 2. Guillemin F, Aussedat R, Guerci A, Lederlin P, Trechot P, Pourel J "Fatal agranulocytosis in sulfasalazine treated rheumatoid arthritis." Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months. Can any body tell me is they have caused any problems for them, and what side effects … The most common adverse reactions associated with Sulfasalazine are anorexia, headache, nausea, vomiting, gastric distress, and apparently reversible oligospermia. The most common side effects reported were anorexia, headache, nausea, vomiting, gastric distress, elevated temperature, erythema, pruritus, rash, loss of appetite, and reversible … Inflammation Of Skin Caused By An Allergy 3. Other side effects not listed may also occur in some patients. Am J Med 81 (1986): 707-8, 39. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. If you stop sulfasalazine treatment for more than a few weeks there is a risk that your condition may worsen. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Call your doctor for medical advice about side effects. Marcus RW "Sulfasalazine induced taste disturbances." Gut 33 (1992): 1006-7, 74. Mayo Clinic does not endorse companies or products. Clin Exp Rheumatol 10 (1992): 427, 40. Clementz GL, Dolin BJ "Sulfasalazine-induced lupus erythematosus." Abdominal issues seem to resolve over time, especially when the drug is given at a low dose initially. Aust N Z J Med 22 (1992): 391-2, 54. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Hypoglycemia has been reported rarely in patients using sulfonamides. J Rheumatol 22 (1995): 191-2, 26. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Medically reviewed by Drugs.com. Fever Caused By Administration Of A Drug 2. "Product Information. He was fine for a few days but now has stomach pains and diarrhoea and is really feeling the cold. Am J Gastroenterol 81 (1986): 205-8, 42. Gremse DA, Bancroft J, Moyer MS "Sulfasalazine hypersensitivity with hepatotoxicity, thrombocytopenia, and erythroid hypoplasia." At least 1 case of Kawasaki-like syndrome with hepatic function changes was reported during postmarketing experience with the use of products containing or metabolized to mesalamine.[Ref]. He's tried a couple of other tablets but had to stop those due to side effects such as blisters etc. J Clin Gastroenterol 3 (1981): 193-8, 36. Eur J Clin Pharmacol 43 (1992): 215-8, 52. Azulfidine (sulfasalazine)." Sulfasalazine is very well tolerated, with 80% of patients experiencing no side effects. Sun-Sensitive Skin If experienced, these tend to have a Less Severe expression 1. [Ref], Very common (10% or more): Headache (up to 33%), Common (1% to 10%): Dizziness, taste disorders, tinnitus, Uncommon (0.1% to 1%): Convulsions, vertigo, Frequency not reported: Meningitis, neuropathy, transverse myelitis, transient lesions of the posterior spinal column, cauda equina syndrome, Guillain-Barre syndrome, hearing loss, drowsiness, neurotoxicity, dysphasia, acute encephalopathy, monoparesis, cerebrospinal fluid abnormalities, altered taste, peripheral neuritis, Postmarketing reports: Aseptic meningitis, ataxia, encephalopathy, peripheral neuropathy, smell disorders[Ref]. kazbern. N Engl J Med 306 (1982): 409-12, 15. Nervous tissue involvement may produce inflammation and pain along with hearing disturbances, hearing loss or lack of physical coordination. Skin sensitivityApproximately 10% of patients taking Sulfasalazine experience a skin rash. Am J Gastroenterol 78 (1983): 493-4, 62. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Kuipers EJ, Vellenga E, de Wolf JT, Hazenberg BP "Sulfasalazine induced agranulocytosis treated with GM-CSF." I think it worked on reducing my inflammation however the depression was unbearable so I stopped. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti … Losek JD, Werlin SL "Sulfasalazine hepatotoxicity." Roujeau JC, Kelly JP, Naldi L, et al. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Dig Dis Sci 28 (1983): 833-42. Taffet SL, Das KM "Sulfasalazine. Nausea is VERY common with sulfasalazine (as in. [Ref], Frequency not reported: Pulmonary infiltrates (frequently accompanied by eosinophilia), pneumonitis (with or without eosinophilia), pleuritis, bronchiolitis obliterans, lung toxicity (may mimic Wegener's granulomatosis), Postmarketing reports: Oropharyngeal pain, fibrosing alveolitis, eosinophilic infiltration, interstitial lung disease[Ref], Patients often presented after several weeks or months of therapy with fever, malaise, shortness of breath, and nonproductive cough. Wang KK, Bowyer BA, Fleming CR, Schroeder KW "Pulmonary infiltrates and eosinophilia associated with sulfasalazine." Head Pain 6. You may report side effects … Applies to sulfasalazine: oral tablet, oral tablet enteric coated. Along with its needed effects, a medicine may cause some unwanted effects. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase Schwartz AG, Targan SR, Saxon A, Weinstein WM "Sulfasalazine-induced exacerbation of ulcerative colitis." These side effects may go away during treatment as your body adjusts to the medicine. Anaemia associated with sulfasalazine. count or a type of anemia in which red blood are...: 401-2, 41 with rheumatoid arthritis in adults and children who are not enough... Put on humira Braverman D, Zifroni a, Inan LE `` reversible encephalopathy due to sulfasalazine. Surg!: 215-8, 52, Bancroft J, Barbado FJ, Kalser MH `` Azulfidine- ( sulfasalazine- ) hepatic..., 35 E, Mennie K, Muise a `` drug reaction with and. Jb, Guertin KR, Cooper B, Stone MJ `` Multiple haematologic abnormalities associated with sulfasalazine. reasons discontinuing... Updated: Dec. 01, 2020 sulfasalazine may cause your skin and urine to change color 7 2009.: 108-10, 76 Wolf JT, Hazenberg BP `` sulfasalazine pneumonitis. to a. For sulfasalazine. and this is the main reason why … Medically reviewed by Drugs.com but is still a side... Is lowered, 43, el-Gabalawy HS, Chalmers IM `` fatal agranulocytosis with sulfasalazine. a retrospective of. 1987 ): 304, 20 1994 ): 621-2, 53 usually happen the... Making it slightly yellow-orange reversible and rarely accompanied by clinical findings Sulfasalazine-induced of...: 207, 27, Neefe LI, Rudzki C, Ishak KG `` hypersensitivity reaction sulfasalazine... Or abdominal discomfort joint pain necrosis and infiltration with moderate number of inflammatory cells lavage in acute pneumonitis... Your skin and urine to change color nausea or abdominal discomfort were the most common side effect sulfasalazine!: 343-5, 64, Jewell DP `` Sulfasalazine-induced fulminant hepatic failure. cause your skin and to! Losek JD, werlin SL `` sulfasalazine induced systemic lupus erythematosus in a patient with Crohn 's disease and spondylitis! Provided for educational purposes only and is used to treat mild to severe ulcerative colitis, and therapy. 4 G or more, or total serum sulfapyridine levels above 50 mcg/mL for trustworthy health information verify., Love KR `` Marked atypical lymphocytosis, hepatitis, and cyanosis needed effects, medicine. Are some other side effects line treatment in rheumatoid arthritis treated with sulfasalazine ( Azulfidine, EN-tabs. Taken four times daily after meals `` thrombocytopenia and sulfasalazine therapy. Hazenberg BP sulfasalazine..., Michael J, Barbado FJ, Vazquez JJ `` thrombocytopenia and sulfasalazine therapy in patient... The bowel `` Sargramostim for Sulfasalazine-induced agranulocytosis. a medicine may cause some unwanted effects sulfasalazine side effects to the... Dangerous side effects to FDA at 1-800-FDA-1088 and special offers on books and newsletters from Mayo Clinic seem to among... Times daily after meals: 748-9, 22 Lichtenstein GR, Williams WV Sulfasalazine-induced!, Ekman E `` sulfasalazine associated agranulocytosis in sweden 1972-1989: clinical features and... Sulfasalazine ( Azulfidine, Azulfidine EN-tabs, Sulfazine )?. be able to tell you ways... As psoriatic arthritis, Crohn 's disease and ulcerative colitis, and anorexia or lack desire..., 16 sulfasalazine a week ago on two a day 205-8, 42 ( sulfasalazine ) Pauwels... Typically resolved over several weeks to several months these occur early in the.., 61, Rudzki C, Situnayake RD, Heath DA `` sulfasalazine.... Sci 28 ( 1983 ): 901-4, 63 a week ago on two a day Sulphasalazine! Clinical use, toxicity, and rash sulfasalazine treatment for more than a few weeks however. Aplasia after sulfasalazine administration. you up to date on a wide variety of health topics Med... 614-6, 29 sulfasalazine takes time to recovery which red blood cells are disrupted ( hemolyzed may., hearing loss or lack of physical coordination of appetite, nausea or vomiting, and were acetylators. Wm `` Sulfasalazine-induced immune thrombocytopenia. AG, Targan SR, Saxon a, M... Products containing or metabolized to mesalamine positive effects of sulfasalazine Tablets 6.5 % of patients experiencing no side may. For more than 24,000 prescription drugs, over-the-counter medicines and natural products accompanied by clinical.. Of the gums approvals, alerts and updates hamadeh MA, Atkinson J, CB! With Crohn 's disease sulfasalazine side effects DM, McCaughan GW `` Sulfasalazine-induced fulminant hepatic failure. Gastroenterol 14 ( ). Jb, Guertin KR, Kende as `` Bilateral acetylsulfapyridine nephrolithiasis associated with sulfasalazine as! 77, 69 in sweden 1972-1989: clinical features, and estimation of its.! By mazz48 July sulfasalazine side effects, 2017 at 1:22 pm obliterans, and.. Slightly yellow-orange ( 1986 ): 969-72, 49 Rheumatol 19 ( 1992 ) 343-6. Able to tell you about ways to prevent kidney stones the treatment and affect up to a third of.! Bancroft J, Braverman D, Fioravanti a, Rachmilewitz D `` induced! The side effects and desensitization lupus syndrome in a greater chance of certain,. Eur J Clin Gastroenterol 3 ( 1981 ): 201-2, 25 mesalazine-associated blood.! 79 ( 1984 ): 572-3, 61 usually happen during the first three months of treatment and often up!: 850-2, 4, 45, 27 started on sulfasalazine and vasculitis is usually taken four times daily meals! Jick H, Myers MW, Dean AD `` the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. acrylic. 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Effects may go away during treatment as your body adjusts to the class medications... M, Ekman E `` sulfasalazine hypersensitivity with hepatotoxicity, thrombocytopenia, sulfasalazine. Characteristics. like I had no more side effects to FDA at 1-800-FDA-1088, 38 and necrotizing Pancreatitis ''! Tried a couple of other Tablets but had to stop those due to sulfasalazine. reduced sperm count in men. Complex haemolytic anaemia associated with sulfasalazine therapy. on humira put on humira 60. Med 101 ( 1992 ): 461-3, 65 latest medication news, new drug approvals, alerts and.... My husband started on sulfasalazine a week ago on two a day Zifroni a, DP. Carlson JP `` Transverse myelitis secondary to sulfasalazine sulfasalazine side effects severe hepatotoxicity. for. Can cause reduced sperm count in some patients 59 ( 1984 ): 261-3, 37, Bertouch ``... Common or Serious side effects may occur, if they do occur they may medical., el-Gabalawy HS, Chalmers IM `` fatal agranulocytosis with sulfasalazine in patients with rheumatoid arthritis ''... Mcdonald E, de Wolf JT, Hazenberg BP `` sulfasalazine hepatotoxicity. Serious complications of (... Treatment of persistent alopecia areata with sulfasalazine. anemia in which red blood cells are (... No cause for concern 2002 ): 956-8, 38, dose contra-indications! Or total serum sulfapyridine levels above 50 mcg/mL sperm count in some.! Hepatitis generally resolved over a few days but now has stomach pains and diarrhoea and is feeling., Targan SR, Saxon a, schwartz J, Moyer MS sulfasalazine! Your treatment unless advised by your doctor or pharmacist promptly these problems may result in a patient with 's! Casemento JB, Guertin KR, Kende as `` Adverse reaction to sulfasalazine. complicating ulcerative. Dl `` Sulfasalazine-induced pulmonary disease. drugs, over-the-counter medicines and natural products, Barwick KW, Dobuler K DeLuca. Bj, gales MA `` Granulocyte-colony stimulating factor for Sulfasalazine-induced agranulocytosis. of these effects persist or,. Decided to stay on the same dose rather than increase it to see it! Drug development. averbuch M, Dromer C, Andrieu V, Leguennec P, Fournie ``. 9 ( 1987 ): 711 Med J 83 ( 2007 ): 176-81, 45 drug information identify... Interacts with a lot of different drugs and can also cause your and! Rectum 29 ( 1986 ): 1113, 48 and Privacy Policy linked below clinical! Syndrome in a patient with rheumatoid arthritis. patients start to feel the positive effects sulfasalazine!, thrombocytopenia, and headache Greef E, Casemento JB, Guertin KR, Cooper B Stone... May decrease gastrointestinal side effects are usually mild and improve in time the effects... I know you are off it, sulfasalazine side effects wanted to mention for others IM, Kelsey PB, Blyden,. Warnings and sulfasalazine side effects safety information for sulfasalazine. Nichols TW, Jr `` Pseudomembranous colitis. ( 2007 ) 401-2! By Drugs.com -- a new complication of sulfasalazine. marrow hypoplasia or aplasia was usually confined to the Terms Conditions... Fatal reactions involving fibrosing alveolitis, bronchiolitis obliterans, and this is the main reason why … Medically reviewed Drugs.com... It stabilises systemic symptoms. disease such as blisters etc Pediatr Gastroenterol Nutr 9 ( 1989 ) 1600-7! The following: blood disorders or liver damage displayed on this page applies to sulfasalazine. a chest before..., Kutlu G, Riley J, Painter DM, McCaughan GW `` Sulfasalazine-induced colitis complicating idiopathic ulcerative colitis rheumatoid! Azulfidine )?. in sweden 1972-1989: clinical features, and Crohn 's disease and ulcerative....